Ensiklopedia

AQP1
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	4CSK , 1FQY , 1H6I , 1IH5
Pengidentifikasi
	AQP1 , AQP-CHIP, CHIP28, CO, aquaporin 1 (Colton blood group)
ID eksternal	107776 103201 68051 AQP1
Lokasi gen (Tikus)
Kr.	Kromosom 6 (tikus)
Akhir	55,325,540 bp
Pola ekspresi RNA
	; ;
	Referensi data ekspresi selengkapnya
Fungsi molekuler	• aktivitas transporter ; • GO:0051739, GO:0015251 aktivitas transporter transmembran amonium ; • aktivitas transporter transmembran nitrogen monoksida ; • aktivitas saluran kation teraktivasi cGMP intraseluler ; • aktivitas saluran kalium ; • GO:0022891 aktivitas transporter transmembran ; • aktivitas transporter transmembran karbon dioksida ; • GO:0001948, GO:0016582 Ikatan protein plasma ; • aktivitas transporter transmembran air ; • GO:0015388 aktivitas transporter transmembran ion kalium ; • aktivitas transporter transmembran gliserol ; • aktivitas saluran air ; • pengikatan reseptor efrin ; • pengikatan protein identik ; • aktivitas saluran ;
Komponen seluler	• sitoplasma ; • membran inti ; • symbiont-containing vacuole membrane ; • membran ; • Inti sel ; • membran plasma apikal ; • komponen integral membran ; • Membran sel ; • apical part of cell ; • basal plasma membrane ; • integral component of plasma membrane ; • brush border membrane ; • membran plasma basolateral ; • Sarkolema ; • brush border ; • symbiont-containing vacuole ; • Akson ; • neuron projection ; • axon terminus ; • extracellular exosome ;
Proses biologis	• cellular response to retinoic acid ; • cellular response to mechanical stimulus ; • cellular response to copper ion ; • cellular response to nitric oxide ; • respons seluler terhadap hipoksia ; • cellular response to cAMP ; • carbon dioxide transmembrane transport ; • positive regulation of fibroblast proliferation ; • cellular homeostasis ; • pancreatic juice secretion ; • cGMP biosynthetic process ; • cellular response to stress ; • cellular response to salt stress ; • cellular response to inorganic substance ; • cell volume homeostasis ; • cellular response to UV ; • establishment or maintenance of actin cytoskeleton polarity ; • negative regulation of apoptotic process ; • cellular response to dexamethasone stimulus ; • positive regulation of angiogenesis ; • odontogenesis ; • renal water transport ; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ; • cellular response to mercury ion ; • nitric oxide transport ; • cellular hyperosmotic response ; • bicarbonate transport ; • positive regulation of saliva secretion ; • renal water homeostasis ; • multicellular organismal water homeostasis ; • transepithelial water transport ; • carbon dioxide transport ; • cellular response to hydrogen peroxide ; • cerebrospinal fluid secretion ; • potassium ion transmembrane transport ; • ammonium transmembrane transport ; • cation transmembrane transport ; • glomerular filtration ; • potassium ion transport ; • transpor air ; • hyperosmotic response ; • response to hormone ; • positive regulation of lamellipodium assembly ; • positive regulation of epithelial cell migration ; • glycerol transport ; • Nosisepsi ; • lateral ventricle development ; • water homeostasis ; • positive regulation of cell migration ; • secretion by cell ; • secretory granule organization ; • wound healing ; • hyperosmotic salinity response ; • response to estrogen ; • lipid digestion ; • camera-type eye morphogenesis ; • corticotropin secretion ; • renal water absorption ; • metanephric descending thin limb development ; • metanephric proximal straight tubule development ; • metanephric proximal convoluted tubule segment 2 development ; • metanephric glomerulus vasculature development ; • GO:0015915 transpor ; • cGMP-mediated signaling ; • ion transmembrane transport ; • transpor transmembran ;
	Sumber: Amigo / QuickGO
	358
	11826
	ENSG00000240583
	ENSMUSG00000004655
	P29972 ; Q6JSD8 ; Q6JSD7
	Q02013
NM_198098 ; NM_000385 ; NM_001185060 ; NM_001185061 ; NM_001185062 ;
	NM_001329872
	NM_007472
	NP_001316801 ; NP_932766
	NP_031498
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Akuaporin 1 adalah protein pada manusia yang dikodekan oleh gen AQP1 .

AQP1 secara luas mengekspresikan saluran air yang fungsi fisiologisnya banyak dikarakteristikkan di dalam ginjal . Protein ini ditemukan pada membran plasma dan apikal tubulus proksimal , lengan menurun lengkung Henle , dan pada bagian menurun . Sebagai tambahan, protein ini juga ditemukan pada sel darah merah , endotelium vaskular, saluran pencernaan , kelenjar keringat , dan paru-paru .

Akuaporin ini tidak diregulasi oleh vasopresin (ADH).

Fungsi

Akuaporin merupakan famili protein membran integral kecil terkait protein intrinsik mayor ( atau AQP0). Gen ini mengodekan akuaporin yang berfungsi sebagai protein saluran air molekuler. Protein ini merupakan homotetramer dengan 6 domain rentangan dwilapis dan situs . Fisik protein menyerupai protein saluran dan melimpah pada eritrosit dan tubulus ginjal. Gen yang mengodekan akuaporin ini menjadi kandidat mungkin untuk kelainan yang melibatkan ketidakseimbangan pada pergerakan cairan okular. ^{[

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Lihat juga

Akuaporin

Referensi

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004655 - , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: AQP1 aquaporin 1 (Colton blood group)" .

Bacaan lanjutan

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van Hoek AN, Wiener MC, Verbavatz JM, Brown D, Lipniunas PH, Townsend RR, Verkman AS (1995). "Purification and structure-function analysis of native, PNGase F-treated, and endo-beta-galactosidase-treated CHIP28 water channels". Biochemistry . 34 (7): 2212– 9. doi : 10.1021/bi00007a015 . PMID 7532004 .
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