Ensiklopedia

Mezlosilin
Nama sistematis ( IUPAC )
	asam (2 S ,5 R ,6 R )-3,3-dimetil-6-[[(2 R )-2-[(3-metilsulfonil- ; 2-okso-imidazolidina-1-karbonil)amino]-2-fenil-asetil] ; amino]-7-okso-4-tia-1-azabisiklo[3.2.0]heptana-2- ; karboksilat
Data klinis
/ Drugs.com	Micromedex Detailed Consumer Information
Kat. kehamilan	B
	?
Rute	Intravena , intramuskular
Data farmakokinetik
Ikatan protein	16–59%
Metabolisme	Hati (20–30%)
Waktu paruh	1,3–4,4 jam
Ekskresi	Ginjal (50%) dan empedu
Pengenal
Nomor CAS	51481-65-3
Kode ATC	CA10
PubChem	CID 656511
DrugBank	DB00948
ChemSpider	570894
UNII	OH2O403D1G
KEGG	D05021
ChEBI	CHEBI:6919
ChEMBL
Data kimia
Rumus	C 21 H 25 N 5 O 8 S 2
SMILES	eMolecules & PubChem
	InChI InChI=1S/C21H25N5O8S2/c1-21(2)14(18(29)30)26-16(28)13(17(26)35-21)22-15(27)12(11-7-5-4-6-8-11)23-19(31)24-9-10-25(20(24)32)36(3,33)34/h4-8,12-14,17H,9-10H2,1-3H3,(H,22,27)(H,23,31)(H,29,30)/t12-,13-,14+,17-/m1/s1 ; Key:YPBATNHYBCGSSN-VWPFQQQWSA-N ;

Mezlosilin adalah antibiotik penisilin berspektrum luas. Obat ini aktif terhadap bakteri gram-negatif dan beberapa bakteri gram-positif . Tidak seperti kebanyakan penisilin berspektrum luas lainnya, obat ini diekskresikan oleh hati, oleh karena itu obat ini berguna untuk infeksi saluran empedu, seperti kolangitis asendens.

Bakteri yang rentan

Gram-negatif

Bacteroides spp., termasuk
spp.
Escherichia coli
Haemophilus influenzae
Klebsiella species
Neisseria gonorrhoeae
Pseudomonas spp., termasuk P. aeruginosa
Serratia marcescens

Gram-positif

Sintesis

Referensi

^ W. Schroeck, H. R. Furtwaengier, H. B. Koenig, and K. G.Metzer, German Offen. 2,318,955 (1973); Chem. Abstr., 82,31313b (1975).
^ H. B. Koenig, K. G. Metzer, H. A. Offe, and W. Schroeck, Eur. J_. Med. Chem., 17, 59 (1982).

Bacaan lebih lanjut

Kristof R, Clusmann H, Koehler W, Fink K, Schramm J (1998). "Treatment of accidental high dose intraventricular mezlocillin application by cerebrospinal fluid exchange" . J Neurol Neurosurg Psychiatry . 64 (3): 379– 81. doi : 10.1136/jnnp.64.3.379 . PMC 2170014 . PMID 9527154 .
McCormick P, Greenslade L, Kibbler C, Chin J, Burroughs A, McIntyre N (1997). "A prospective randomized trial of ceftazidime versus netilmicin plus mezlocillin in the empirical therapy of presumed sepsis in cirrhotic patients". Hepatology . 25 (4): 833– 6. doi : 10.1002/hep.510250408 . PMID 9096584 . S2CID 45046625 .
Rohde B, Werner U, Hickstein H, Ehmcke H, Drewelow B (1997). "Pharmacokinetics of mezlocillin and sulbactam under continuous veno-venous hemodialysis (CVVHD) in intensive care patients with acute renal failure". Eur J Clin Pharmacol . 53 (2): 111– 5. doi : 10.1007/s002280050347 . PMID 9403281 . S2CID 20525389 .

Pranala luar

Duke

[1] W. Schroeck, H. R. Furtwaengier, H. B. Koenig, and K. G.Metzer, German Offen. 2,318,955 (1973); Chem. Abstr., 82,31313b (1975).

[2] H. B. Koenig, K. G. Metzer, H. A. Offe, and W. Schroeck, Eur. J_. Med. Chem., 17, 59 (1982).

[ 1 ]

[ 2 ]


Nama sistematis ( IUPAC )
asam (2 S ,5 R ,6 R )-3,3-dimetil-6-[[(2 R )-2-[(3-metilsulfonil- 2-okso-imidazolidina-1-karbonil)amino]-2-fenil-asetil] amino]-7-okso-4-tia-1-azabisiklo[3.2.0]heptana-2- karboksilat
Data klinis
/ Drugs.com	Micromedex Detailed Consumer Information
Kat. kehamilan	B
	?
Rute	Intravena , intramuskular
Data farmakokinetik
Ikatan protein	16–59%
Metabolisme	Hati (20–30%)
Waktu paruh	1,3–4,4 jam
Ekskresi	Ginjal (50%) dan empedu
Pengenal
Nomor CAS	51481-65-3 ^Y
Kode ATC	CA10
PubChem	CID 656511
DrugBank	DB00948
ChemSpider	570894 ^Y
UNII	OH2O403D1G ^Y
KEGG	D05021 ^Y
ChEBI	CHEBI:6919 ^Y
ChEMBL	^Y
Data kimia
Rumus	C ₂₁ H ₂₅ N ₅ O ₈ S ₂
SMILES	eMolecules & PubChem
InChI InChI=1S/C21H25N5O8S2/c1-21(2)14(18(29)30)26-16(28)13(17(26)35-21)22-15(27)12(11-7-5-4-6-8-11)23-19(31)24-9-10-25(20(24)32)36(3,33)34/h4-8,12-14,17H,9-10H2,1-3H3,(H,22,27)(H,23,31)(H,29,30)/t12-,13-,14+,17-/m1/s1 ^Y Key:YPBATNHYBCGSSN-VWPFQQQWSA-N ^Y