Ensiklopedia

IL6
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	4O9H , 1ALU , 1IL6 , 1P9M , 2IL6 , 4CNI , 4J4L , 4NI7 , 4NI9 , 4ZS7
Pengidentifikasi
	IL6 , BSF2, HGF, HSF, IFNB2, IL-6, BSF-2, CDF, IFN-beta-2, interleukin 6
ID eksternal	147620 96559 502 IL6
Lokasi gen (Tikus)
Kr.	Kromosom 5 (tikus)
Akhir	30,224,979 bp
Pola ekspresi RNA
	Referensi data ekspresi selengkapnya
Fungsi molekuler	• cytokine activity ; • growth factor activity ; • interleukin-6 receptor binding ; • GO:0001948, GO:0016582 Ikatan protein plasma ;
Komponen seluler	• extracellular region ; • interleukin-6 receptor complex ; • extracellular space ; • endoplasmic reticulum lumen ;
Proses biologis	• regulation of angiogenesis ; • positive regulation of translation ; • platelet activation ; • humoral immune response ; • defense response to virus ; • response to peptidoglycan ; • neuron projection development ; • GO:0051637 defense response to Gram-positive bacterium ; • negative regulation of fat cell differentiation ; • positive regulation of peptidyl-serine phosphorylation ; • positive regulation of leukocyte chemotaxis ; • positive regulation of T cell proliferation ; • positive regulation of interleukin-6 production ; • positive regulation of peptidyl-tyrosine phosphorylation ; • positive regulation of acute inflammatory response ; • inflammatory response ; • negative regulation of collagen biosynthetic process ; • positive regulation of MAPK cascade ; • hepatic immune response ; • monocyte chemotaxis ; • positive regulation of DNA-binding transcription factor activity ; • negative regulation of apoptotic process ; • positive regulation of osteoblast differentiation ; • positive regulation of NF-kappaB transcription factor activity ; • acute-phase response ; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 respons imun ; • regulation of vascular endothelial growth factor production ; • positive regulation of chemokine production ; • negative regulation of lipid storage ; • neutrophil mediated immunity ; • positive regulation of smooth muscle cell proliferation ; • positive regulation of type B pancreatic cell apoptotic process ; • response to glucocorticoid ; • GO:0051636 defense response to Gram-negative bacterium ; • positive regulation of cell population proliferation ; • positive regulation of apoptotic process ; • positive regulation of B cell activation ; • modifikasi pascatranslasi ; • regulation of signaling receptor activity ; • positive regulation of tyrosine phosphorylation of STAT protein ; • neutrophil apoptotic process ; • negative regulation of cell population proliferation ; • GO:1901313 positive regulation of gene expression ; • endocrine pancreas development ; • negative regulation of bone resorption ; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated ; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II ; • glucagon secretion ; • cellular response to hydrogen peroxide ; • cellular response to lipopolysaccharide ; • T-helper 17 cell lineage commitment ; • positive regulation of T-helper 2 cell cytokine production ; • negative regulation of interleukin-1-mediated signaling pathway ; • cytokine-mediated signaling pathway ; • interleukin-6-mediated signaling pathway ; • positive regulation of receptor signaling pathway via JAK-STAT ; • GO:0072468 signal transduction ;
	Sumber: Amigo / QuickGO
	3569
	16193
	ENSG00000136244
	ENSMUSG00000025746
	P05231
	P08505
	NM_000600 ; NM_001318095 ; NM_001371096
	NM_031168 ; NM_001314054
	NP_000591 ; NP_001305024 ; NP_001358025
	NP_001300983 ; NP_112445
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Interleukin-6 ( bahasa Inggris : Interleukin 6, Interferon beta-2, IFNB2, B cell differentiation factor, B cell stimulatory factor 2, BSF2, Hepatocyte stimulatory factor, HSF, Hybridoma growth factor, HGF, IL-6 ) adalah sitokina yang di sekresi dari jaringan tubuh ke dalam plasma darah , terutama pada fase infeksi akut atau kronis, dan menginduksi respon peradangan transkriptis melalui pencerap IL-6 RA, menginduksi maturasi sel B . ^{[

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Rujukan

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025746 - , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ (Inggris) "IL6 interleukin 6 (interferon, beta 2) [ Homo sapiens ]" . Entrez Gene . Diakses tanggal 2010-07-29 .
^ (Inggris) "INTERLEUKIN 6; IL6" . OMIM . Diakses tanggal 2010-07-29 .

Artikel bertopik biokimia ini adalah sebuah rintisan . Anda dapat membantu Wikipedia dengan .

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000025746 - , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[4] (Inggris) "IL6 interleukin 6 (interferon, beta 2) [ Homo sapiens ]" . Entrez Gene . Diakses tanggal 2010-07-29 .

[5] (Inggris) "INTERLEUKIN 6; IL6" . OMIM . Diakses tanggal 2010-07-29 .

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