Ensiklopedia

Aprikoksib
Nama sistematis ( IUPAC )
	4-[2-(4-Ethoxyphenyl)-4-methyl-1 H -pyrrol-1-yl]benzenesulfonamide
Data klinis
Kat. kehamilan	?
	?
Pengenal
Nomor CAS	162011-90-7
Kode ATC	?
PubChem	CID 9820073
ChemSpider	7995822
UNII	5X5HB3VZ3Z
KEGG	D08657
Data kimia
Rumus	C 19 H 20 N 2 O 3 S
SMILES	eMolecules & PubChem
	InChI InChI=1S/C19H20N2O3S/c1-3-24-17-8-4-15(5-9-17)19-12-14(2)13-21(19)16-6-10-18(11-7-16)25(20,22)23/h4-13H,3H2,1-2H3,(H2,20,22,23) ; Key:JTMITOKKUMVWRT-UHFFFAOYSA-N ;

Aprikoksib merupakan obat antikanker eksperimental. Aprikoksib digolongkan sebagai inhibitor COX-2 yang digunakan untuk meningkatkan respon pengobatan pada penyakit kanker pankreas. ^{[

1

]} Pengembangan aprikoksib dihentikan pada tahun 2015 dikarenakan hasil uji klinik yang cukup buruk. ^{[

2

]}

Referensi

^ Kirane A, Toombs JE, Ostapoff K, Carbon JG, Zaknoen S, Braunfeld J, Schwarz RE, Burrows FJ, Brekken RA (September 2012). "Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer" . Clinical Cancer Research . 18 (18): 5031– 42. doi : 10.1158/1078-0432.CCR-12-0453 . PMC 3777527 . PMID 22829202 .
^ "Apricoxib" . Adis Insight . Springer Nature Switzerland AG.

[1] Kirane A, Toombs JE, Ostapoff K, Carbon JG, Zaknoen S, Braunfeld J, Schwarz RE, Burrows FJ, Brekken RA (September 2012). "Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer" . Clinical Cancer Research . 18 (18): 5031– 42. doi : 10.1158/1078-0432.CCR-12-0453 . PMC 3777527 . PMID 22829202 .

[2] "Apricoxib" . Adis Insight . Springer Nature Switzerland AG.

[ 1 ]

[ 2 ]

Obat antiinflamasi nonsteroid
golongan /	Aminofenazon Metamizol Oksifenbutazon Fenilbutazon Propifenazon Sulfinpirazon ^‡
Turunan asam salisilat	Aspirin ^# Aloksiprin Benorilat Magnesium salisilat Salsalat Salisin Asam salisilat Natrium salisilat
Turunan Asam asetat	Diklofenak Etodolak Indometasin Indometasin farnesil Ketorolak ^†
Oksikam	Isoksikam Meloksikam Piroksikam Tenoksikam
Turunan asam propionat (profens)	^† ^‡ Deksibuprofen Deksketoprofen Fenoprofen Flurbiprofen Ibuprofen ^# Indoprofen ^† Ketoprofen Miroprofen Naproksen Oksaprozin ^‡ ^‡ :
Asam N -antranilat ( fenamat )	Etofenamat Asam flufenamat Asam meklofenamat Asam mefenamat Asam niflumat Asam tolfenamat
	Aprikoksib ^‡ ^‡ Etorikoksib ^‡ ^† ^‡ Parekoksib ^‡ ^† ^†
Lainnya	Benzidamin Glukosamin Nabumeton
Item yang diberi tanda tebal menandakan pengembangan senyawa dari kelompok tertentu. ^# WHO-EM ^† . ^‡ .


Nama sistematis ( IUPAC )
4-[2-(4-Ethoxyphenyl)-4-methyl-1 H -pyrrol-1-yl]benzenesulfonamide
Data klinis
Kat. kehamilan	?
	?
Pengenal
Nomor CAS	162011-90-7
Kode ATC	?
PubChem	CID 9820073
ChemSpider	7995822
UNII	5X5HB3VZ3Z
KEGG	D08657
Data kimia
Rumus	C ₁₉ H ₂₀ N ₂ O ₃ S
SMILES	eMolecules & PubChem
InChI InChI=1S/C19H20N2O3S/c1-3-24-17-8-4-15(5-9-17)19-12-14(2)13-21(19)16-6-10-18(11-7-16)25(20,22)23/h4-13H,3H2,1-2H3,(H2,20,22,23) Key:JTMITOKKUMVWRT-UHFFFAOYSA-N

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Referensi

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