Ensiklopedia

AQP3
Pengidentifikasi
	AQP3 , AQP-3, GIL, aquaporin 3 (Gill blood group)
ID eksternal	600170 1333777 21025 AQP3
Fungsi molekuler	• aktivitas saluran air ; • glycerol channel activity ; • aktivitas transporter ; • aktivitas saluran ; • urea transmembrane transporter activity ;
Komponen seluler	• sitoplasma ; • komponen integral membran ; • membran ; • cell-cell junction ; • Membran sel ; • membran plasma basolateral ; • Inti sel ;
Proses biologis	• positive regulation of immune system process ; • Ekskresi ; • respons terhadap vitamin D ; • respons terhadap asam retinoat ; • transpor air ; • urea transport ; • odontogenesis ; • response to calcium ion ; • renal water homeostasis ; • regulation of keratinocyte differentiation ; • renal water absorption ; • glycerol transport ; • cellular response to oxygen-glucose deprivation ; • respons seluler terhadap hipoksia ; • transpor transmembran ; • urea transmembrane transport ;
	Sumber: Amigo / QuickGO
	360
	11828
	ENSG00000165272
	ENSMUSG00000028435
	Q92482
	Q8R2N1
	NM_004925 ; NM_001318144
	NM_016689
	NP_001305073 ; NP_004916
	NP_057898
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Akuaporin 3 ditemukan pada membran sel basolateral sel utama dan menyediakan jalur bagi air untuk keluar dari sel tersebut. ^{[

3

]} Di dalam ginjal, AQP3 diregulasi oleh vasopresin (ADH). ^{[

4

]} Protein ini juga merupakan determinan untuk sistem golongan darah GIL. ^{[

5

]}

(SAHA) ( ) meningkatkan ekspresi akuaporin-3 pada sel kulit normal ( ). ^{[

6

]}

Signifikansi klinis

Konsentrasi AQP3 sering kali lebih rendah pada psoriasis dibandingkan dengan kulit sehat. ^{[

6

]}

AQP3 lebih diekspresikan pada eksem atopik . ^{[

7

]}

Lihat pula

Akuaporin

Referensi

^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct". Annu. Rev. Physiol . 60 : 199– 220. doi : 10.1146/annurev.physiol.60.1.199 . PMID 9558461 .
^ Baynes JW, Dominiczak MH (2014). "Medical Biochemistry" . Medical Biochemistry (Textbook) (Edisi 4): 346 – via Elsevier.
^ Roudier N, Ripoche P, Gane P, Le Pennec PY, Daniels G, Cartron JP, Bailly P (2002). "AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL". J. Biol. Chem . 277 (48): 45854– 9. doi : 10.1074/jbc.M208999200 . PMID 12239222 . Pemeliharaan CS1: DOI bebas tanpa ditandai ( link )
^ ^a ^b Cancer therapy shows promise for psoriasis treatment
^ Olsson M, Broberg A, Jernãs M, et al. (2006). "Increased expression of aquaporin 3 in atopic eczema". Allergy . 61 (9): 1132– 7. doi : 10.1111/j.1398-9995.2006.01151.x . PMID 16918518 .

Bacaan lanjutan

Bietz S, Montilla I, Külzer S, et al. (2009). "Recruitment of human aquaporin 3 to internal membranes in the Plasmodium falciparum infected erythrocyte". Mol. Biochem. Parasitol . 167 (1): 48– 53. doi : 10.1016/j.molbiopara.2009.04.006 . PMID 19393693 .
Bahamontes-Rosa N, Tena-Tomás C, Wolkow J, et al. (2008). "Genetic conservation of the GIL blood group determining aquaporin 3 gene in African and Caucasian populations". Transfusion . 48 (6): 1164– 8. doi : 10.1111/j.1537-2995.2008.01683.x . PMID 18435676 .
Wang S, Amidi F, Beall M, et al. (2006). "Aquaporin 3 expression in human fetal membranes and its up-regulation by cyclic adenosine monophosphate in amnion epithelial cell culture". J. Soc. Gynecol. Investig . 13 (3): 181– 5. doi : 10.1016/j.jsgi.2006.02.002 . PMID 16638588 .
Ben Y, Chen J, Zhu R, et al. (2008). "Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells". Respiratory physiology & neurobiology . 161 (2): 111– 8. doi : 10.1016/j.resp.2007.12.007 . PMID 18280225 .
Yasui H, Kubota M, Iguchi K, et al. (2008). "Membrane trafficking of aquaporin 3 induced by epinephrine". Biochem. Biophys. Res. Commun . 373 (4): 613– 7. doi : 10.1016/j.bbrc.2008.06.086 . PMID 18601899 .
Horie I, Maeda M, Yokoyama S, et al. (2009). "Tumor necrosis factor-alpha decreases aquaporin-3 expression in DJM-1 keratinocytes". Biochem. Biophys. Res. Commun . 387 (3): 564– 8. doi : 10.1016/j.bbrc.2009.07.077 . PMID 19619514 .
Bellemère G, Von Stetten O, Oddos T (2008). "Retinoic acid increases aquaporin 3 expression in normal human skin". J. Invest. Dermatol . 128 (3): 542– 8. doi : 10.1038/sj.jid.5701047 . PMID 17943189 .
Cohly HH, Isokpehi R, Rajnarayanan RV (2008). "Compartmentalization of aquaporins in the human intestine" . Int J Environ Res Public Health . 5 (2): 115– 9. doi : 10.3390/ijerph5020115 . PMC 2694936 . PMID 18678926 . Pemeliharaan CS1: DOI bebas tanpa ditandai ( link )
Lee TC, Ho IC, Lu WJ, Huang JD (2006). "Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line". J. Biol. Chem . 281 (27): 18401– 7. doi : 10.1074/jbc.M601266200 . PMID 16672223 . Pemeliharaan CS1: DOI bebas tanpa ditandai ( link )
Hara-Chikuma M, Verkman AS (2008). "Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing". J. Mol. Med . 86 (2): 221– 31. doi : 10.1007/s00109-007-0272-4 . PMID 17968524 .
Hara-Chikuma M, Takahashi K, Chikuma S, et al. (2009). "The expression of differentiation markers in aquaporin-3 deficient epidermis" . Arch. Dermatol. Res . 301 (3): 245– 52. doi : 10.1007/s00403-009-0927-9 . PMC 3582396 . PMID 19184071 .
Wang J, Tanji N, Kikugawa T, et al. (2007). "Expression of aquaporin 3 in the human prostate". Int. J. Urol . 14 (12): 1088– 92, discussion 1092. doi : 10.1111/j.1442-2042.2007.01901.x . PMID 18036046 .
Higuchi S, Kubota M, Iguchi K, et al. (2007). "Transcriptional regulation of aquaporin 3 by insulin". J. Cell. Biochem . 102 (4): 1051– 8. doi : 10.1002/jcb.21350 . PMID 17471492 .
Tancharoen S, Matsuyama T, Abeyama K, et al. (2008). "The role of water channel aquaporin 3 in the mechanism of TNF-alpha-mediated proinflammatory events: Implication in periodontal inflammation". J. Cell. Physiol . 217 (2): 338– 49. doi : 10.1002/jcp.21506 . PMID 18543247 .
Richardson SM, Knowles R, Marples D, et al. (2008). "Aquaporin expression in the human intervertebral disc". J. Mol. Histol . 39 (3): 303– 9. doi : 10.1007/s10735-008-9166-1 . PMID 18247144 .
Avril-Delplanque A, Casal I, Castillon N, et al. (2005). "Aquaporin-3 expression in human fetal airway epithelial progenitor cells". Stem Cells . 23 (7): 992– 1001. doi : 10.1634/stemcells.2004-0197 . PMID 16043462 .
Kida H, Miyoshi T, Manabe K, et al. (2005). "Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line". J. Membr. Biol . 208 (1): 55– 64. doi : 10.1007/s00232-005-0819-7 . PMID 16596446 .
Liu YL, Matsuzaki T, Nakazawa T, et al. (2007). "Expression of aquaporin 3 (AQP3) in normal and neoplastic lung tissues". Hum. Pathol . 38 (1): 171– 8. doi : 10.1016/j.humpath.2006.07.015 . PMID 17056099 .

Pranala luar

Sistem golongan darah GIL pada Basis Data Mutasi Gen Antigen Golongan Darah di NCBI , NIH
Lokasi genom AQP3 manusia dan halaman rincian gen AQP3 dalam .

Artikel bertopik biokimia ini adalah sebuah rintisan . Anda dapat membantu Wikipedia dengan .

[1] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[2] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid9558461-3] Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct". Annu. Rev. Physiol . 60 : 199– 220. doi : 10.1146/annurev.physiol.60.1.199 . PMID 9558461 .

[pmid9824541-4] Baynes JW, Dominiczak MH (2014). "Medical Biochemistry" . Medical Biochemistry (Textbook) (Edisi 4): 346 – via Elsevier.

[pmid12239222-5] Roudier N, Ripoche P, Gane P, Le Pennec PY, Daniels G, Cartron JP, Bailly P (2002). "AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL". J. Biol. Chem . 277 (48): 45854– 9. doi : 10.1074/jbc.M208999200 . PMID 12239222 . Pemeliharaan CS1: DOI bebas tanpa ditandai ( link )

[MCG2017-6] Cancer therapy shows promise for psoriasis treatment

[7] Olsson M, Broberg A, Jernãs M, et al. (2006). "Increased expression of aquaporin 3 in atopic eczema". Allergy . 61 (9): 1132– 7. doi : 10.1111/j.1398-9995.2006.01151.x . PMID 16918518 .

[ 1 ]

[ 2 ]

[ 3 ]

[ 4 ]

[ 5 ]

[ 6 ]

[ 7 ]